This work provides starting guide for simple Postfix mail server configuration. Then I configured the Postfix mail server to support Anti-Spam and Anti-Virus, using two methods. – Method 1: With Postfix, SpamAssassin, ClamAV and Amavis-new- Method 2: With Postfix, SpamAssassin, ClamAV and ProcmailThe report includes the following sections- How Postfix receives mail:- How Postfix delivers mail- Starting guide for quick Postfix configuration- Postfix mail server and Dovecot configuration- Installing ClamAV and SpamAssassin- Installing and configuring Squirrelmail:- Method 1 to support Antivirus and Antispam: Using Postfix, Amavis-new, ClamAV, SpamAssassin- Method 2 to support Antivirus and Antispam: Using Postfix, Procmail, ClamAV, SpamAssassin.